Corrected CO depletion factors, ${f^{\prime }}_D$, as a function of gas density (i.e. number density of H nuclei, n_H; left panel) and dust temperature (right panel). We also report the CO depletion values measured by Entekhabi et al. (2022) in Cloud C as orange squares. In both panels, the horizontal dotted black line corresponds to ${f^{\prime }}_D=1$. In the right panel, we also show the empirical relation reported by Kramer et al. (1999) that was derived in the low-mass core IC 5146 (blue curve) (see Eq. (1)). We also show our derived IRDC depletion relation (see Eq. (8)) (red curve).