Synthetic spectra using NIRSpec/G395H instrument mode. The detection threshold for the 4.45 µm feature of CH₃CN for three different flat continua (from top to bottom: 1, 0.1, and 0.04 mJy) used to model different targets with decreasing brightnesses is shown. A synthetic noise extracted from previous observations (McClure et al. 2023) was added to the continuum. The black spectrum is the column density of CH₃CN that was increased iteratively to achieve a 5σ detection with respect to the flat continuum (dashed blue line).